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doi: 10.1136/gutjnl-2017-315542 7

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Serious Side Effects: More severe, though less common, adverse events include acute pancreatitis (inflammation of the pancreas), gallbladder issues (including gallstones), kidney problems (especially in cases of severe dehydration from gastrointestinal issues), and vision changes, particularly in individuals with diabetic retinopathy

There is a direct correlation between its expression level and Tregs' ability to inhibit ( A critical layer of complexity arises from the functional heterogeneity and phenotypic plasticity within the Treg compartment