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AI tools, in addition, have been developed to predict therapy responses (pathological complete response (pCR), neoadjuvant chemotherapy) based on treatment MRI scans and molecular profiles (304)

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The comparator groups differed among studies, with some employing placebo controls (e.g., PIONEER-6, Gerstein 2019), others using active comparators such as sitagliptin, glimepiride, DPP-4 inhibitors, or SGLT2 inhibitors, and some utilizing standard care or intensive lifestyle interventions as the control

For reconstitution, sterile water for injection or the provided diluent is used

Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma