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While the exact mechanism behind the effect of thyroid hormone on protein metabolism is not fully elucidated, it is believed to be mediated by a combination of mitochondria-dependent cytoplasmic mechanisms, and modulation of nuclear genetic transcription of genes involved in protein metabolism (475-477)
Arch Biochem Biophys 300:201205 Schuit F, de Vos A, Farfari S et al (1997) Metabolic fate of glucose in purified islet cells
PT-141 may cause a temporary increase in blood pressure in some individuals, although this is not common
Luckily, severe and persistent gastroparesis appears to be very rare
That boxed warning had been in place since 2003, based largely on data from the Women's Health Initiative study