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It exerts various physiological effects by acting on the area postrema in the brainstem

Multi-dose pens (after first use): Ozempic (semaglutide): May be stored at room temperature (up to 86F/30C) for up to 56 days or kept refrigerated after first use [1] [2] Victoza and Saxenda (liraglutide): May be kept at room temperature (up to 86F/30C) for up to 30 days or refrigerated after first use Byetta (exenatide): May be kept at room temperature (up to 77F/25C) for up to 30 days after first use Single-dose pens (before use): Wegovy (semaglutide): May be stored at room temperature (up to 86F/30C) for up to 28 days before use [1] [2] Trulicity (dulaglutide): May be stored at room temperature (up to 86F/30C) for up to 14 days before use Mounjaro and Zepbound (tirzepatide): May be stored at room temperature (up to 86F/30C) for up to 21 days before use Bydureon BCise (exenatide extended-release): May be stored at room temperature (up to 77F/25C) for up to 4 weeks before use Patients should write the date of first use on multi-dose pen labels to track how long the medication has been in use

Gerstein et al., 2019)

However, the decentralization of prescribing also introduces variability

J Clin Endocrinol Metab 63: 492-498, 1986

When fiber is fermented by gut bacteria, it produces short-chain fatty acids that help stimulate GLP-1 release