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High concentrations for IV use should be diluted in normal saline or another compatible IV fluid before administration

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After incubation of fibroblasts with 500 microM of OHCbl, a 75% decrease of intracellular cyanide was observed, with concomittant formation of intracellular cyanocobalamin CNCbl (intracellular/extracellular ratio: 158)

Pernicious anaemia , an autoimmune condition affecting intrinsic factor production in the stomach, represents the most common indication