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Food and Drug Administration has approved various PQQNa 2 dietary supplements, with no reported side effects (Akagawa et al., 2016a)

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Vitamin B12 supplements can help treat or prevent a vitamin B12 deficiency, which can be serious and Not everyone needs to take a vitamin B12 supplement, as However, healthcare professionals may recommend vitamin B12 supplements for certain populations, including: people following a vegan diet older adults people who have had gastrointestinal surgery people who have nutrient absorption issues people with dietary restrictions People taking certain long-term medications, such as metformin and proton pump inhibitors, may also benefit from a supplement, as these medications can affect absorption of vitamin B12

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Circulation 128 , 834844 (2013)