Factors such as individual health status, wound characteristics, and potential interactions with other medications should be carefully considered when determining the appropriateness and dosage of glutathione treatment for wound healing
Diabetic wound models showed a 9-fold increase in collagen synthesis, better epithelialization, and activation of fibroblasts and mast cells
This creates feed-forward cycles that exacerbate cuproptosis: mtROS oxidize cytosolic GSH, releasing bound Cu, and may upregulate the copper importer CTR1 via pathways such as NF-B, increasing copper influx [65]
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They also make it impossible to know what helped, what harmed, and what did nothing
