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If headaches persist beyond two weeks or become severe, this warrants attention
High doses may cause temporary headaches due to increased NAD+ turnover and mitochondrial activity
GPs can prescribe B12 injections following appropriate investigation, which should include: Full blood count to identify macrocytic anaemia Serum B12 and folate levels to confirm deficiency (using laboratory-specific reference ranges) Methylmalonic acid and/or homocysteine when B12 results are borderline Intrinsic factor antibodies if pernicious anaemia is suspected Additional tests depending on clinical presentation (e.g., thyroid function, coeliac serology) When both B12 and folate deficiency are present, B12 should be replaced before folate to avoid precipitating subacute combined degeneration of the spinal cord
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Methylated vitamins are specially formulated versions of certain B vitamins, like B12 and folate (B9), that are more easily absorbed and utilized by the body
Recognizing these risks can aid in preventive measures and early diagnosis
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