Initially, many patients notice a significant reduction in hunger and a greater sense of fullness within the first few weeks as the dose is gradually increased
Visceral fat is strongly associated with cardiovascular disease, type 2 diabetes, and certain cancers
This may lead to headaches and fatigue
The slightly higher side effect rate is a tradeoff for significantly better weight loss results
In addition, the GLP-1 can inhibit postprandial gastric emptying and reduce gastric acid secretion, inhibit gastric and duodenal peristalsis by inhibiting vagus nerve, and increase the pressure of pylorus, thus reducing appetite, causing a reduction in body weight and participating in the so-called ileal braking effect (19, 35)
Medications containing semaglutide and tirzepatide are commonly linked to stomach-related side effects because they strongly affect appetite and digestion