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Military Med Res

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The influx of calcium ions promotes the fusion of insulin-secreting vesicles with the cell membrane, leading to enhanced insulin secretion, which maintains glucose homeostasis [1] (Fig

In vivo animal experiments showed that daily administration of NNMTi for 28 days to dietinduced obese (DIO) mice significantly upregulated the expression of lipolysisrelated genes (such as ATGL and HSL) and downregulated lipogenesisrelated genes (such as FAS and ACC), indicating that NNMTi effectively promotes fat breakdown and inhibits fat synthesis