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Thus, any impairment to either of the system Xc -glutathione-GPX4 axis compromises the conversion of lipid peroxides to the corresponding alcohols, ultimately hampering the GPX4 antioxidant effect and giving rise to ferroptosis ( Nuclear factor erythroid 2-related factor 2 (Nrf2) has been found to be a key regulator in inhibiting ferroptosis

In the early stage of heat stroke, abdominal B-ultrasound and liver computed tomography (CT) usually show no obvious abnormalities

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