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Two recent clinical studies also reported remarkably upregulated PPAR expression in red blood cells, boosted serum GSH and GPX levels and decreased serum MAD contents after treatment with curcumin (500 mg/day, P.O for 8 weeks

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Although latencies in the STZ group tended to be shorter, suggesting weakened memory retention, this pattern aligns with previous evidence indicating that STZ-induced cognitive deficits are more pronounced during early and short-term memory phases and may exhibit greater variability in long-term memory processes

While most clinical evidence supports a favorable safety profile at typical therapeutic doses, caution is warranted as higher doses may cause sedation, cardiovascular effects such as hypotension and arrhythmias, and, in rare cases, respiratory depression