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Negative energy balance and weight loss can activate the hypothalamic-pituitary-adrenal axis, elevating cortisol levels

[DOI] [PubMed] [Google Scholar] The initial clinical evidence of potential BMT benefit in female patients with impaired sexual arousal

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Pro-inflammatory cytokines from activation of microglia can lead to the formation of A1 astrocytes, which are implicated in the pathogenesis of glaucoma and have diminished ability to phagocytose and poorer synapse support [96, 97]