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Other biomarkers explored, but ultimately not determined suitable, for this method were the liver factors IGF binding protein (IGFBP)-2, IGFBP-3, and acid-labile subunit (ALS), and bone turnover markers procollagen type I carboxyl-terminal propeptide and type 1 collagen cross-linked carboxy-terminal telopeptide (Barroso et al., 2008)

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Teeth adjacent to the cleft have a higher incidence of malformation and malposition, and frequently require restoration due to caries or esthetic concerns (Figures 10A and 10B)