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Weekly semaglutide at 2.4 mg can achieve weight reductions of 10%12%, while tirzepatide has even demonstrated marked improvement in specific trials, reaching 5%20%+ ( More importantly, cardiovascular and renal outcome studies have demonstrated that GLP-1RAs and related multi-receptor agonists not only lower body weight and blood glucose but also significantly reduce the risk of major adverse cardiovascular events (MACE) and the worsening of renal function

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