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It represents the molecule's oxidation state: NAD+ has a net positive charge because the nicotinamide ring has lost one electron, creating an electron-deficient nitrogen atom with a formal +1 charge

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Dillon JS, Tanizawa Y, Wheeler MB, Leng XH, Ligon BB, Rabin DU, Yoo-Warren H, Permutt MA, and Boyd AE, 3rd