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The standard protocol begins with 0.25 mg once weekly for four weeks, increasing to 0.5 mg, with further increases to 1 mg or 2 mg only if needed and tolerated

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Although Phase 2 data have demonstrated impressive cardiometabolic benefits, retatrutide remains unlicensed by the MHRA and EMA, meaning its full side-effect profile including any musculoskeletal effects is not yet formally established

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Jing Y, Zhu J, Liu T, Bi S, Hu X, Chen Z et al (2015) Structural characterization and biological activities of a novel polysaccharide from cultured Cordyceps militaris and its sulfated derivative