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A dominant role of the glutathione system over the thioredoxin system in mediating anti-oxidant electron flux in planta is consistent with our observations in yeast, and the concept of the ascorbate-glutathione cycle as the dominant route of NADP-dependent anti-oxidant electron flux in plants

269 In this regard, high SIRT6 levels have been reported in colon cancer samples, which correlate with worse prognosis