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In this edition of Then and Now, it is useful to look back 25 years and reflect upon the developments in this field since Nauck and colleagues published two seminal papers

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Concerning etiology of the phenotype, they suggest that upon admission, all patients should have serum obtained for measurement of amylase or lipase level, triglyceride level, calcium level, and liver chemistries. Invasive evaluation, such as endoscopic retrograde cholangiopancreatography (ERCP), should be avoided for patients with a single occurrence of AP

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