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For weight-loss regimens: Wegovy and many compounded protocols use weekly escalations to 0.25, 0.5, 1.0, 1.7, and 2.4 mg, with each step typically held for 4 weeks to assess tolerance

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Sustained restriction at that level leads to muscle loss, hair thinning (telogen effluvium), fatigue, and nutritional deficiencies and makes long-term weight maintenance harder because it reduces your metabolic rate

doi:10.1007/s00428-019-02671-0

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La raccomandazione FDA di passare a un metodo non orale (vaginale, transdermico, dispositivo intrauterino) o di aggiungere un metodo di barriera per 30 giorni dallinizio della terapia e per 30 giorni dopo ogni aumento di dose