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Following this, selected compounds were analyzed through pharmacophore generation and MD simulations

J Clin Transl Sci 2:334342 Heeney MM, Abboud MR, Githanga J, Inusa BP, Kanter J, Michelson AD, Nduba V, Musiime V, Apte M, Inati A, Taksande AM (2022) Ticagrelor vs placebo for the reduction of vaso-occlusive crises in pediatric sickle cell disease: the HESTIA3 study

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Special Populations Renal Insufficiency A single-dose, open-label study was conducted to evaluate the pharmacokinetics of Januvia (50 mg dose) in patients with varying degrees of chronic renal insufficiency compared to normal healthy control subjects