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The FDA did attach a boxed warning for embryo-fetal toxicity, flagging the risk of major birth defects when used during pregnancy

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However, the use time and effect of GLP-1RAs, and the adverse reactions after long-term use must also be fully paid attention to and studied before clinical application

Other intranasal preparations being explored in Parkinsons include dopamine, one using gene therapy, a vitamin E loaded naringenin, stem cells, glial cell-derived neurotrophic factor (GDNF), carnosine, BDNF, intranasal insulin, rotigotine, and estradiol

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