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In summary, long-acting GLP-1R agonists primarily reach the circumventricular organs of the hindbrain and food-intake controlling centers of the hypothalamus

A clinician may consider it when metformin alone is not enough, when sitagliptin is already part of the regimen, or when a fixed-dose combination could reduce pill burden

However, electrophysiological studies revealed that GLP-1 or exendin-4 does not change the spontaneous firing activity as well as the synaptic transmission suggesting lack of functional GLP-1R in PPG neurons (Hisadome et al., 2010)

Limitations and Candidacy This section exists because it is the most important one for a GLP-1 patient trying to make a well-informed decision

Each Use: Before drawing a dose, swab the stopper with alcohol

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