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UNPYSCT-2018070), Chen Xiao-Ping Foundation For The Development Of Science And Technology Of Hubei Province (Grant No

This mitochondrial fraction is functionally critical, as demonstrated by the restoration of ferroptosis sensitivity in CHAC1-null cells through expression of a mitochondrially targeted CHAC1 (Ward et al., 2024)

In 24 hpi trophozoite-stage parasites, hemoglobin and heme levels were not measurably different, but hemozoin levels were significantly decreased in resistant parasites compared to sensitive parasites (Fig 2B), indicative of decreased turnover of heme into hemozoin in resistant parasites over the preceding 24 h of the parasite lifecycle

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