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Activation of 1 receptors increases intracellular cAMP, which: Activates protein kinase A (PKA) Phosphorylates L-type calcium channels Increases calcium influx into the cell Calcium entry triggers calcium-induced calcium release (CICR) from the sarcoplasmic reticulum via ryanodine receptors, increasing intracellular calcium available to bind troponin C, thereby enhancing myocardial contractility (positive inotropy)

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doi:10.3390/v15010225 Benahmed AG, Noor S, Menzel A, Gasmi A

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Retatrutide is a triple agonist that adds glucagon receptor activity to the GLP-1/GIP profile