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In the co-culture system, MCECs derived from the model group exhibited significant reduced ZO-1 and Occludin expression compared to those from the Control group, whereas GHK-Cu elevated theses protein levels (Figures 4GI)

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The decisive nuance, however, lies in the correction: once BMC was normalised to the gain in body weight, the apparent advantage disappeared, and volumetric cortical bone mineral density (BMD) remained unchanged

Inhibition of the Xc-system, inactivation of GPX4 and overloading of iron ions are the three most critical factors leading to ferroptosis