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Glaviano et al., 2023), kaempferol (Wang R

Furthermore, disruption of GLS1 signalling using gene depletion or the use of the Gln inhibitor CB-839 will also lead to ubiquitination of c-MYC proteins, creating a GLS1-c-MYC positive feedback loop

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Nevertheless, clinical translation is still in its nascent stage and encounters considerable challenges, such as suboptimal pharmacokinetic profiles, safety issues, and the requirement for precise therapeutic approaches