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Males were dosed for 4 weeks prior to mating, and females were dosed for 2 weeks prior to mating and throughout organogenesis until Gestation Day 17

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2.4 Exposure definition The primary exposure was GLP-1 RA use, defined as any documented prescription fill for a GLP-1 RA (liraglutide, semaglutide, exenatide, and dulaglutide) at least 90 days prior to the index date, based on prescription records in the electronic health record

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Microbiota-derived metabolites and pathways Changes in the microbiota brought on by GLP-1RAs are associated with changes in key microbial metabolite patterns that may impact host metabolism

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