510% weight loss is considered clinically meaningful with pharmacotherapy
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The research on this is pretty new, but it will be interesting to see whether part of the reason MAO inhibitors work for depression is due, at least in part, to decreasing neuroinflammation, which is a root cause of depression for some people.[ref] Related article : Inflammation as a cause of depression MAOA: Heart valves and varicose vein connections I mentioned above that MAO-A is found abundantly in the heart