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discovered that the combined effect of METH and HIV-1 Tat induces oxidative stress, increasing ferroptosis in BV2 microglial cells, thereby elevating HAND risk

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[PubMed: 8637535] 38

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If this theory is correct, then increasing antioxidant capacity should increase organismal life span and ameliorate these devastating diseases

Furthermore, NAD + plays a key role in several essential cellular processes including DNA repair, immune cell function, senescence, and chromatin remodeling 520