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doi: 10.1111/jdv.19238 70

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As illustrated in Figure 1, the side chains on amino acids in positions 1, 4, 6, and 9 are assumed to face downward where they can contact binding pockets located in the floor of the binding groove, locking the peptide into the HLA molecule ( Class II HLA alleles can be subdivided into HLA-DR, HLA-DP, and HLA-DQ alleles

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