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From Diabetes Treatment to Obesity Medicine: Semaglutide's Evolution Semaglutide was originally developed as a once-weekly injectable GLP-1 receptor agonist for type 2 diabetes management, receiving FDA approval in December 2017 under the brand name Ozempic

[DOI] [PMC free article] [PubMed] [Google Scholar] Patel KR, Cherian J, Gohil K, Atkinson D

It led to a 21 percent drop in body weight, on average, at the highest dose (compared with 3 percent for the placebo)

(3) Structural optimization to enhance CD36 affinity improves permeability and drug potency

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