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Additional populations comprise specialized anti-adipogenic, profibrotic, inflammatory, and fibroblast-like ASPCs

National Institute of Aging

NEJM Evidence

The current study Study author Yuya Koide and his colleagues wanted to explore how individuals with type 2 diabetes respond to GLP-1RAs therapy (Koide et al., 2025)

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FDA-approved GLP-1 medications like semaglutide (Ozempic, Wegovy) are structurally modified to resist breakdown, have half-lives of days rather than minutes, and produce sustained receptor activation that results in greater glucose-lowering effects and clinically significant weight loss