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Description

10.3390/ijms25179255 81

Oxidative Medicine and Cellular Longevity, 2021 , 2074610

, 400 ( 200 )

There are well-known synthetic peptides that are FDA-approved, effective medicine

Studies have used MT-II in direct comparison with MT-1 to characterise how cyclisation of the -MSH pharmacophore core changes receptor subtype selectivity , establishing that constraining the heptapeptide into a cyclic conformation shifts selectivity toward MC3R/MC4R relative to the linear tridecapeptide that preferentially activates MC1R