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Conversely, certain metabolites, such as secondary bile acids and trimethylamine N-oxide (TMAO), have been implicated in processes associated with DNA damage, genomic instability, and angiogenesis, fostering an environment conducive to carcinogenesis [31,32]

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Thus, the Ser/Thr kinase AMPK is activated during energy depletion, when the AMP/ATP ratio increases and triggers a large number of downstream effectors by stimulating ATP-generating catabolic pathways and inhibiting anabolic pathways in order to restore the energy balance

Malonaldehyde formation and DNA fragmentation: two independent sperm decays linked to reactive oxygen species

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