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Tirzepatide activates GIP and GLP-1 receptors in the exocrine pancreas, promoting a reduction in blood glucose levels and aiding in the management of type 2 diabetes (T2D) [1]
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Approximately 27% of participants were on background SGLT2 inhibitor therapy at baseline
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- MASH affects 6% of US adults - Linked to liver cancer, transplant risk, and cardiometabolic complications - First approved therapy targeting both metabolic dysfunction and fibrotic progression Clinical Implications - Early intervention now has a validated pharmacologic option - Opens doors for multidisciplinary care across hepatology, endocrinology, and primary care - Reinforces the role of GLP-1 therapies beyond diabetes and obesity Your Voice Matters: How will semaglutides approval reshape your approach to managing MASH and liver fibrosisespecially in high-risk or underserved populations
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