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More studies are required to investigate regulation at the protein level, and effects on the phosphorylation status of GSK3 following induction by GLP-1R agonists to further elucidate the mechanism of action

Updated February 2026 | 10 min read If youve been following the conversation around GLP-1 and fat loss, you already know that drugs like Ozempic and Wegovy have completely reshaped the weight-loss landscape

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doi: 10.1056/NEJMc0809750