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The STEP trials demonstrated that semaglutide produces weight loss averaging 1522% over 68 weeks, while the SURMOUNT trials showed tirzepatide achieves 2022% weight reduction

CHALLENGES TO DEVELOPMENT In developing the second-generation amylin-analog cagrilintide there were 2 main barriers: (1) to prevent amylin protein aggregation and (2) to extend the amylin-analogs half-life

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The dosing protocol is not as strict with metformin, but users taking it once daily should take it at night with their final meal

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Mykkanen L, Kuusisto J, Haffner SM, Laakso M, Austin MA