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85 One-carbon metabolism and cysteine bioavailability The de novo synthesis of cysteine cannot be addressed without mentioning the involvement of serine and glycine in the one-carbon pathway

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However, liver enlargement and regeneration activated by PXR cause YAP to undergo deacetylation and K63-linked ubiquitination in a Sirt2-dependent manner, which allows YAP-TEAD binding in the nucleus

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