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To determine the tolerable upper intake level (UL), the FNB selected adverse reproductive effects in rats as the most sensitive index of toxicity and applied a large uncertainty factor because animal data were used (2)

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Additionally, hypoglycemia, although more likely in combination with other glucose-lowering medications, is a potential risk associated with overdose due to Semaglutides insulinotropic effects

Most participants maintained a small residual elevation above their pre-treatment heart rate throughout the study

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