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Mutations can also occur in the principal Nrf2 repressor, Keap1 or component of the E3 ubiquitin-ligase complex Cullin 3 (CUL3), with loss of function that renders these factors unable to bind Nrf2 and thus result in persistent Nrf2 activation [68]

It is usually well tolerated, but rare serious complications such as VPA-induced hepatotoxicity (VHT) and VPA-induced hyperammonaemic encephalopathy (VHE) may occur in some patients who receive VPA chronically [133]

Expression profiling of uterine leiomyomata cytogenetic subgroups reveals distinct signatures in matched myometrium: transcriptional profilingof the t(12;14) and evidence in support of predisposing genetic heterogeneity

Furthermore, long-term exposure of cancer cells to acidic extracellular conditions induces metabolic reprogramming toward glutamine metabolism via HIF-2 activity 71

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