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A patient who lost 55 pounds in eight months on semaglutide may have different tissue features than someone who lost the same amount with lifestyle changes over two to three years

For a large portion of the population, that was always going to be a dealbreaker

These combined mechanisms contribute to an extended elimination half-life of approximately 5.6 to 7.5 days [28]

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In combination with insulin (with or without metformin), JANUVIA provided significant improvements in A1C, FPG, and 2-hour PPG compared to placebo (Table 14)

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