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Such substrate-dependent inhibition profiles could offer distinct therapeutic advantages (Crettol et al

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PPI, protein-protein interaction

The risk may be higher when used with other medicines that lower potassium

For instance, drugs, like proton pump inhibitors (PPIs) and H2 receptor antagonists, which are often prescribed for reflux treatment, can lessen the stomach's ability to produce acid

Another real-world study published in PMC examined patients with type 2 diabetes and confirmed that tirzepatide users had greater HbA1c and weight reductions at 12 months compared to injectable semaglutide users, regardless of whether they had previous GLP-1 receptor agonist experience