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After sample extraction, three internal standards (IS, 13C5NAD, 13C 2,6,7 NAM, and 6,7-dimethyl-2,3-di(2-pyridyl)-quinoxaline [DMDPQ]) were added to all samples (blanks, standards, quality controls [QC], and tissue extracts)

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Insulin/sulfonylureas: increased hypoglycemia risk

This increased glutathione pool may help contend with the increased flow of free radicals from dysfunctional mitochondria