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Since CPP-CAND was designed to interfere with the FOXO4-p53 interaction, we investigated the disruption of FOXO4-p53bp1 foci in the nucleus of senescent cells after CPP-CAND treatment

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In vivo investigations were conducted through a randomized, double-blind, placebo-controlled clinical study that enrolled 21 healthy subjects

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Changes in serum calcitonin concentrations, incidence of medullary thyroid carcinoma, and impact of routine calcitonin concentration monitoring in the exenatide study of cardiovascular event lowering (EXSCEL)