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Tirzepatide produces average weight loss of approximately 20% to 22.5% at its highest approved dose of 15 mg over 72 weeks

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For patients with COMISA (comorbid insomnia and sleep apnea), some studies have shown that starting CBT-I before beginning positive airway pressure (PAP) therapy leads to better PAP adherence and greater improvement in insomnia symptoms compared to starting PAP without prior CBT-I 4,5

Nonetheless, certain mechanisms associated with its method of action and metabolic impacts may potentially affect skin health leading to an outbreak of acne