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This directly impacts the NAD+/NADH ratio, a fundamental determinant of cellular energy status and metabolic flexibility

Kidney disease is also extremely common in people with type 1 diabetes

Some participants in clinical trials have reported difficulty falling or staying asleep, particularly in the early weeks of treatment, though whether this reflects a direct drug effect remains uncertain

Additionally, Metformin has been found to have protective effects on the body and musculoskeletal system, especially in females

What Should You Tell Your Healthcare Provider