glutathione autism link Mitochondrial dysfunction reveals H2S-mediated synaptic sulfhydration as a potential mechanism for autism-associated social defects: Cell Metabolism The Interplay of Oxidative Stress,

(Peptide Sciences) Comparative advantage and specificity Researchers note that many senolytics suffer from off-target cytotoxicity (i.e., they kill healthy cells too)

Calza et al

J Stat Softw

To this end, we used Annexin-V to specifically identify apoptotic cells, and 7-AAD to evaluate cells with progressive loss of membrane permeability, i.e., dead cells

doi: 10.1210/jc.2006-1821 59 YuLZhouLXuEBiYHuXPeiXet al

Thus, we have demonstrated that GSH-targeted therapy selectively kills PC cells in an oxidative stress-dependent manner and that the differences in basal ROS level and antioxidant scavenging capacity induced by stratified expression of VRK2 can well account for the heterogeneous sensitivity to GSH inhibition