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In a double blinded placebo-controlled study, weekly injections of retatrutide (12 mg) in obese patients, in conjunction with lifestyle changes, showed average weight decreases of 22.1% over placebo patients after 48 weeks

Hepatology 33 , 10981109 (2001)

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oral semaglutide requires strict conditions Weight loss : Injectable semaglutide (14.9%) exceeds orforglipron (12.4%)