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A network arises in adolescents and adults presumably provoked by sun exposure

Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs

Xu et al., 2021

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The body adjusts during a break, and restarting at the previous dose without re-titration leads to a strong return of GI side effects